Technology Overview

Collabody™ is a unique fusion protein design platform that utilizes a short triplex-forming collagen-like peptide as a scaffold protein binder for fusing with antibody fragments, hormones, cytokines, lymphokines, growth factors, lectins, enzymes, soluble receptor fragments, and chemo agents.  Collabody™ can also be engineered as bispecific antibodies, enabling novel mechanisms for treating cancer, autoimmune diseases, and infectious diseases.

Technical Superiority

1. Trimeric collagen antibody scaffold enhances binding strength and stability

2. Efficient cellular internalization, enabling antibody–drug complexes to enter tumor cells and improve therapeutic efficacy

3. Collabody™ can fuse not only antibodies but also various functional proteins

4. The collagen scaffold is non-immunogenic, resulting in lower drug side effects

Application

1. Targeted therapy – The collagen scaffold can be fused with protein-based therapeutics, including antibodies, toxins, hormones, cytokines, and enzymes.

2. Molecular imaging – The collagen scaffold can be fused with fluorescent or luminescent proteins, or conjugated with radioisotopes or nanoprobes for imaging applications.

3. Diagnostic reagent development – With its multivalent binding properties, the collagen scaffold significantly enhances antibody–antigen affinity, reducing antibody usage and increasing detection sensitivity.