Technology Overview

ITRI developed iKNOBeads, the world’s first micron-sized magnetic beads with controllable multi-protrusion morphology for immune cell activation. These beads provide high reproducibility and strong activation efficiency, and their surface modifications can be tailored to stimulate different immune cell types.

Combined with ITRI’s optimized manufacturing process, iKNOBeads enable high-yield, high-quality production of CAR-T and NK cells, outperforming leading international products and delivering cells with enhanced cytotoxicity and therapeutic potency.

Technical Superiority

1. The unique multi-protrusion design shortens the CAR-T cell manufacturing process by 30–45%, providing critical time benefits for cancer patients.

2. Using proprietary key materials, the technology increases T cell expansion efficiency by 20% while reducing magnetic bead usage by 66%, significantly lowering treatment costs.

Application

1. Cell therapy and cell isolation applications

2. Demonstrates superior NK cell expansion efficiency from peripheral blood and cord blood compared to commercial products, making it a key material for next-generation allogeneic cell therapies.